92 articles - From Saturday Feb 25 2023 to Saturday Mar 04 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Am J Gastroenterol |
ACG Clinical Guideline: Diagnosis and Management of Biliary Strictures. Recent evidence has provided some clarity in multiple important areas pertaining to biliary strictures, whereas several remaining controversies require additional research. The goal of this guideline is to provide practicing clinicians with the most evidence-based guidance on the approach to patients with extrahepatic and perihilar strictures, focusing on diagnosis and drainage. |
| J Hepatol |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
Randomised, placebo-controlled trial and meta-analysis show benefit of ondansetron for irritable bowel syndrome with diarrhoea: The TRITON trial. Although small numbers meant the primary endpoint was not met in this trial, when pooled with other similar trials meta-analysis suggests ondansetron improves stool consistency and reduces days with loose stool and urgency. |
| Clin Gastroenterol Hepatol |
Systematic Review and Meta-analysis: Efficacy of Mesalamine in Irritable Bowel Syndrome. Mesalamine may be modestly efficacious for global symptoms in IBS, particularly IBS with diarrhea, but quality of evidence was low. Adequately powered high quality RCTs of mesalamine in IBS are needed. |
| Endosc Int Open |
Global trends in training and credentialing guidelines for gastrointestinal endoscopy: a systematic review. While some metrics such as ADR were relatively consistent among societies, there was substantial variation among societies with respect to procedural volume and KPI statements. |
| Endoscopy |
| Gastrointest Endosc |
Long-term outcomes of local resection versus surgical resection for high-risk T1 colorectal cancer: A systematic review and meta-analysis. For high-risk T1 CRC patients, the net benefit of DSS appears to be significant when the observation period exceeds 10 years. A long-term net benefit may exist but may not be applicable to al patients, especially high-risk patients with comorbidities. Therefore, LR may be a reasonable alternative for individualized treatment for some high-risk T1 CRC patients. |
| J Hepatol |
Anticoagulation improves survival in patients with cirrhosis and portal vein thrombosis: The IMPORTAL competing-risk meta-analysis. Anticoagulation reduces all-cause mortality in patients with cirrhosis and portal vein thrombosis independently of recanalization, but at the expense of increasing non-portal hypertension related bleeding IMPACT AND IMPLICATIONS PROSPERO REGISTRATION NUMBER CRD42020140026. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
Effectiveness of golimumab intensification in ulcerative colitis: A multicentric prospective study. In this prospective multicentric study, half of patients recaptured response following golimumab intensification in UC. Therapeutic drug monitoring did not predict response after optimisation of golimumab. |
Mitochondrial respiratory chain activity is associated with severity, corticosteroid response and prognosis of alcoholic hepatitis. Our results indicate that MRC activity is markedly decreased in the liver of AH patients, and, particularly, the impairment of MRC complexes I and III activity appears to have a significant impact on the clinical outcomes of patients with AH. |
| Am J Gastroenterol |
Is Vaccination Against COVID-19 Associated With Inflammatory Bowel Disease Flare? Self-Controlled Case Series Analysis Using the UK CPRD. Vaccination against COVID-19 was not associated with IBD flares regardless of prior COVID-19 infection and whether messenger RNA or DNA vaccines were used. |
The impact of patient age and corticosteroids in patients with Sulfonamide hepatotoxicity. Sulfonamide hepatotoxicity is characterized by a short drug latency with frequent hypersensitivity features at onset. Subject age is an important determinant of the laboratory profile at presentation and patients with cholestasis and higher total bilirubin levels were at increased risk of developing chronic DILI. Corticosteroids may benefit a subgroup of patients with severe injury but further studies are needed. |
| Clin Gastroenterol Hepatol |
Novel Symptom Subgroups in Individuals with Irritable Bowel Syndrome Predict Disease Impact and Burden. Our clusters identify groups of individuals with significant impairments in quality of life, earning potential, and ability to work and function socially, who are high utilizers of healthcare. |
Sarcopenia Among Patients with Nonalcoholic Fatty Liver Disease (NAFLD) is Associated with Advanced Fibrosis. Patients with sarcopenic NAFLD are at risk for SF and AF. Increased physical activity and a healthy diet targeted to improve sarcopenic NAFLD could reduce the risk of significant fibrosis. |
Socioeconomic disparities affect outcomes in early-stage esophageal adenocarcinoma - a SEER analysis. Lower median household income was associated with higher rates of cancer-specific mortality and lower rates of endoscopic resection in T1aN0M0 esophageal adenocarcinoma. Population-based strategies aimed at identifying and rectifying possible etiologies for these socioeconomic and geographic disparities are paramount to improving patient outcomes in early esophageal cancer. |
| Endosc Int Open |
Endoscopic full-thickness resection (EFTR) compared to submucosal tunnel endoscopic resection (STER) for treatment of gastric gastrointestinal stromal tumors. This study demonstrated that although patients who received EFTR had longer hospital stays and slower resumption of diet compared to those who underwent STER, EFTR achieved a significantly higher rate of en-bloc resection compared to STER for treatment of gastric GIST. |
Endoscopic vacuum-assisted closure therapy for leakage of the lower gastrointestinal tract: multicenter experiences. E-VAC therapy due to post-surgery leakage of the lower gastrointestinal tract is safe and effective. High levels of CRP are a negative predictor of E-VAC therapy success. |
EUS-guided cyanoacrylate injection into the perforating vein versus direct endoscopic injection in the treatment of gastric varices. EUS-guided CYA injection into the perforating veins achieved less amount of CYA, fewer number of sessions to obliteration, and similar overall AE rates in the treatment of high-risk GVs compared to DEI. |
Prospective study on the efficacy of endoscopic through-the-scope tack and suture system for gastric peroral endoscopic myotomy mucosal incision site closure. With experience, technical success is high, and most closures may be achieved using a single TTS suture system alone, which has important cost and time implications. Additional comparative trials with other closure devices are need1ed. |
| Endoscopy |
A simple clinical score can stratify the risk of procedure-related adverse events in ERCP procedures with trainee involvement. Simple, clinical-based predictive tools, could improve ERCP training through an individualized selection of cases for hands-on training, with the aim of increasing patient safety. |
Appendiceal lesions in serrated polyposis patients are easily overlooked but only seldomly lead to colorectal cancer. Appendiceal lesions are common in SPS patients. The discrepancy between the endoscopic detection rate of appendiceal lesions and the reported prevalence in surgically resected appendices suggests a substantial miss-rate of appendiceal lesions during colonoscopy. Advanced appendiceal lesions are however rare and no appendiceal adenocarcinomas occurred, implying limited clinical relevance of these lesions. |
ENDOSCOPIC VACUUM THERAPY FOR ESOPHAGEAL PERFORATION: A MULTICENTER RETROSPECTIVE COHORT STUDY. EVT is a promising organ-preserving treatment for esophageal perforations, with a success rate of 89%. More experience with the technique and indications will likely improve success rate. |
Multicenter randomized trial comparing diagnosis sensitivity and cellularity abundance of aggressive and standard biliary brushing for bile duct stenosis without mass syndrome. Sensitivity for cholangiocarcinoma was 34/43 (79%) for the Infinity brush versus 29/43 (67%) for the RX Cytology Brush (p = 0.096). Cellularity was rich in 31/51 (61%) cases with the Infinity brush and in 10/51 (20%) cases with the RX Cytology Brush (p . |
| Gastroenterology |
Colorectal Cancer Risk Assessment and Precision Approaches to Screening: Brave New World or Worlds Apart? In order to envisage clinical implementation of precision screening in the future, it will be critical to develop reliable and accurate prediction models that apply to al individuals in a population, prospectively study risk-adapted CRC screening on the population level, garner acceptance from patients and providers, and assess feasibility, resources, cost, and cost-effectiveness of these new paradigms. This review evaluates the current state of risk prediction modeling and provides a roadmap for future implementation of precision CRC screening. |
Comparing time to diagnosis and treatment between younger and older adults with colorectal cancer: A population-based study. Younger adults present more often with Stage IV colorectal cancer but have overall similar times from presentation to treatment as screening-eligible older adults. |
Disruption of SLFN11 deficiency-induced CCL2 signaling and macrophage M2 polarization potentiates anti-PD-1 therapy efficacy in hepatocellular carcinoma. SLFN11 serves as a critical regulator of microenvironmental immune properties and an effective predictive biomarker of ICIs response in HCC. Blockade of CCL2/CCR2 signaling sensitized SLFN11 low HCC patients to ICI treatment. |
Targeting UBE2T potentiates gemcitabine efficacy in pancreatic cancer by regulating pyrimidine metabolism and replication stress. Collectively, UBE2T-mediated p53 degradation confers PC gemcitabine resistance by promoting pyrimidine biosynthesis and alleviating replication stress. This study offers an opportunity to improve PC survival by targeting UBE2T and develop a promising gemcitabine sensitizer in clinical translation setting. |
| Gastrointest Endosc |
Effect of a deep learning-based automatic upper gastrointestinal endoscopic reporting system: a randomized crossover study. AI-EARS showed its efficacy in improving the accuracy and completeness of the EGD reports. It might facilitate the generation of complete endoscopy reports and post-endoscopy patient management. (ClinicalTrails.gov, number NCT05479253). |
Endoscopic causes and characteristics of missed gastric cancers after endoscopic submucosal dissection. We identified MGCs in four categories and clarified their characteristics. Quality improvements in EGD observation, with attention to the risks of perceptual and site of exposure errors, can potentially prevent missing EGCs. |
| Gut |
Definition of age-dependent reference values for the diameter of the common bile duct and pancreatic duct on MRCP: a population-based, cross-sectional cohort study. This is the first population-based study delineating age-adjusted upper reference limits of CBD and PD on MRCP. We showed that up to 18.2% of healthy volunteers would have needed diagnostic workup, if the conventional reference values were used. The utilisation of the adapted reference levels may help to avoid unnecessary investigations and thus to reduce healthcare expenditure and test-related adverse events. |
Patient selection for urgent endoscopic retrograde cholangio-pancreatography by endoscopic ultrasound in predicted severe acute biliary pancreatitis (APEC-2): a multicentre prospective study. In patients with predicted severe acute biliary pancreatitis without cholangitis, urgent EUS-guided ERCP with ES did not reduce the composite endpoint of major complications or mortality, as compared with conservative treatment in a historical control group. |
SDCBP promotes pancreatic cancer progression by preventing YAP1 from ß-TrCP-mediated proteasomal degradation. SDCBP promotes the proliferation and metastasis of PDAC by preventing YAP1 from ß-TrCP-mediated proteasomal degradation. Therefore, ZnPT could be a promising therapeutic strategy to inhibit PDAC progression by suppressing SDCBP. |
| Hepatology |
Alcohol-induced extracellular asc specks perpetuate liver inflammation and damage in alcoholic hepatitis even after alcohol cessation. Our study demonstrates the central role of NLRP3 and ASC in alcohol-induced liver inflammation and unravels the critical role of ex-ASC specks in the propagation of systemic and liver inflammation in AH. Our data also identify NLRP3 as a potential therapeutic target in AH. |
Gut microbiome-brain-cirrhosis axis. Clinical studies and animal models have demonstrated significant patterns of gut dysbiosis when cirrhosis is present, both with or without concomitant alcohol use disorder, and have provided compelling evidence that this dysbiosis also influences cognitive and mood-related behaviors. In this review, we have summarized the pathophysiological and cognitive effects associated with cirrhosis, links to cirrhosis-associated disruption of the gut microbiome, and the current evidence from clinical and pre-clinical studies for modulation of the gut microbiome as a treatment for cirrhosis and associated neuropsychiatric conditions. |
Implementing pragmatic clinical trials in hepatology. A trial's pragmatism is based on the efficiency by which it identifies, recruits, and follows patients, the degree to which the interventions and design mirrors usual clinical care, and the importance of the outcomes to the patients. We review the promise, tradeoffs, and purpose of pragmatic trials in hepatology. |
The evolving knowledge on primary hemostasis in patients with cirrhosis: A comprehensive review. Further investigations into the in vivo interplay between platelets, circulating blood elements, and endothelial cells may help advance our understanding of cirrhotic coagulopathy. Here, we review the complex changes in platelets and primary hemostasis in cirrhosis, and their potential clinical implications. |
| J Hepatol |
MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells. The miRNomes of CCA tissues are highly remodelled, impacting transcriptome homeostasis in part through regulation of transcription factors like FOXO1. MiR-27a-3p arises as an oncogenic vulnerability in CCA. Impact and implications Cholangiocarcinogenesis entails extensive cellular reprogramming driven by genetic and non-genetic alterations, but the functional roles of these non-genetic events remain poorly understood. By unveiling global miRNA upregulation in patient tumours and their functional ability to increase proliferation of cholangiocytes, these small non-coding RNAs are implicated as critical non-genetic alterations promoting biliary tumour initiation. These findings identify possible mechanisms for transcriptome rewiring during transformation, with potential implications for patient stratification. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
| Clin Gastroenterol Hepatol |
"Alcohol-associated liver disease: integrated management with alcohol use disorder". Progress has recently been made in the management of patients severe AH which have improved survival through better understanding of the concept of response to medical treatment, improved survival prediction and the advent of early LT. The emerging concept is that listing for transplantation a patient with severe ALD could lead to adjusting the duration of abstinence according to the severity and evolution of liver dysfunction and the patient's addictive profile. |
| Endosc Int Open |
| Gastroenterology |
The Gut Microbial Bile Acid Modulation and its Relevance to Digestive Health and Diseases. We also highlight the emerging role for modifying the gut microbiome to improve health or to treat disease, including the "engineered native bacteria'' approach that takes bacterial strains from a patient, modifies them to alter metabolism, and re-introduces them. Taken together, study of the metabolites derived from the gut microbiome will provide insights into a wide range of physiological and pathophysiological processes, and has substantial potential for new approaches to diagnostics and therapeutics of disease of or involving the gastrointestinal tract. |
| J Hepatol |
| Neurogastroenterol Motil |
Improving access to gut-directed hypnotherapy for irritable bowel syndrome in the digital therapeutics' era: Are mobile applications a "smart" solution? While adherence was low, those that completed smart phone-delivered GDH-achieved symptom benefit. This mini-review summarizes the current evidence-base for available modalities of GDH and discusses the current and future utility and development of mobile health applications in the digital therapeutics' era. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastrointest Endosc |
Letters to the editors and authors’ replies
| Clin Gastroenterol Hepatol |
| Gut |
| J Hepatol |